Since we have very recently found that oral administration of 10 mg/kg telmisartan (the same dosage used here) for 2 weeks does not affect BP levels in spontaneously hypertensive rats stroke-prone infused with Ang II (unpublished data), our present observations suggest that telmisartan may improve insulin sensitivity in these animals partly in a BP-independent manner. The gene discussed is INS; the disease is Stroke.