In the presented here study we aimed to assess if blood levels of endogenous sex steroid hormones (total testosterone, free testosterone index, estradiol and dehydroepiandrosterone sulfate) or sex hormone binding globulin (SHBG) may be predictive for biochemical coronary risk factors (blood lipid profile) or the degree of coronary artery stenosis in a large cohort of male patients with stable CAD in the prospectively projected study. This evidence concerns the gene SHBG and coronary artery disorder.