BCR and chronic myelogenous leukemia, BCR-ABL1 positive: Chronic myeloid leukemia (CML) is a myeloproliferative disorder that accounts for a large fraction of adult leukemias and is cytogenetically characterised by the presence of the Philadelphia chromosome (Ph), which originates from a reciprocal translocation between the long arms of chromosomes 9 and 22 and leads to the formation of a novel fusion gene called bcr-abl, the product of which is the oncogenic chimeric kinase BCR-ABL that is involved in the pathogenesis of CML [76].