In this respect, an observational analysis of patients from the Cholesterol and Recurrent Events (CARE) trial found a positive association between apoE in HDL and the risk of coronary events.13 This might explain the positive association between plasma apoE and CVD in some studies, given that about 40% to 50% of apoE is found on HDL.5 Nevertheless, our results suggest that the relatively minor fraction of plasma apoE that is found in LDL may have a remarkable impact on the risk of CHD. The gene discussed is APOE; the disease is coronary artery disorder.