Even though only 1.5% to 16% of LDL contain apoC‐III,3 the idea that apoE can effectively protect against the risk provided by these particles is very appealing if one considers that LDL with apoC‐III are very strongly associated with CHD19 and that in fact much of the CHD risk ordinarily attributed to total LDL may be due to this subpopulation that contains apoC‐III.20 This evidence concerns the gene APOE and coronary artery disorder.