In the 2 US cohorts of men and women, the relative risk of a first coronary event was 2.4 for LDL with apoC‐III compared with 1.2 for LDL without apoC‐III,20 and the test for interaction was significant demonstrating that the prediction of CHD risk by the 2 types of LDL differed significantly. The gene discussed is APOC3; the disease is coronary artery disorder.