A higher content of apoE in VLDL+LDL with apoC‐III was associated with a markedly lower risk of CHD (relative risk for top versus bottom quintile 0.43, 95% CI 0.30 to 0.62; P for trend <0.001), and apoE in VLDL+LDL with apoC‐III continued to show a protective association after adjustment for major cardiovascular risk factors, body mass index, and personal history of diabetes (relative risk 0.53, 95% CI 0.35 to 0.79; P for trend 0.002) (Table 2 and Figure 2). The gene discussed is APOE; the disease is coronary artery disorder.