In these cohorts, we have found the association of LDL with apoC‐III with CHD to be markedly and significantly greater than that of LDL without apoC‐III.20 In the present study, the primary result is that a higher apoE content per each LDL with apoC‐III (apoE content per particle) predicted a markedly lower risk of CHD (relative risk for top versus bottom quintile 0.45, 95% CI 0.31 to 0.64), which continued to be significant after multivariable adjustment (Table 2 and Figure 2). Here, APOC3 is linked to coronary artery disorder.