An association between circulating thyroid peroxidase antibodies (TPOAb) and miscarriage has been found by a number of observational studies and confirmed by a recent meta-analysis [1] (Thyroid peroxidase is an enzyme that helps produce the thyroid hormones T3 and T4, by liberating iodine so it can be added to tyrosine residues on thyroglobulin). The gene discussed is TPO; the disease is spontaneous abortion.