PRKCZ and type 2 diabetes mellitus: Our findings demonstrate that methylation can be observed in peripheral blood leukocyte DNA from both the T2DM and normal control groups but that the prevalence of methylation of the PRKCZ promoter in peripheral blood leukocytes is significantly higher in the T2DM group (77%) than in the normal control group (7%) (χ2 = 36.42, P < 0.01).