This study aimed to firstly characterise a range of adipokines (adiponectin, leptin, Tumour Necrosis Factor-α (TNF-α)) within age-gender-matched groups of South asians with normal glucose tolerance (NGT), impaired glucose tolerance (IGT) and Type 2 Diabetes mellitus (T2DM) and secondly determine adipocytokine interactions with known predictors of metabolic risk and insulin resistance within this group. This evidence concerns the gene LEP and type 2 diabetes mellitus.