NOS1AP and type 2 diabetes mellitus: We detected four proteins showing significant differences between CC and AA carriers of rs12742393 in NOS1AP. Although we failed to validate these differences in the large sample cohort, we suggested that these four proteins might associate with the development of type 2 diabetes in subgroup of patients through the crosstalk with NOS1AP protein, which might provide us a new perspective to the mechanism of type 2 diabetes.