Missense mutations or small deletions in some genes, for example, desmin (Des), integrin-linked protein kinase (Ilk), myosin regulatory light chain 2 (My12), dystrophin (Dmd), gelsolin (Gsn), lamin A/C (Lmna), and laminin subunit α-2 (Lama2), have been linked to cardiomyopathy. Here, DES is linked to cardiomyopathy.