It is those amounts of visceral fat accumulation that would cause lipid oxidative stress and promote adipose tissue to secrete inflammatory adipokines, such as interleukin- (IL)-6, tumor necrosis factor-α (TNF-α), and macrophage chemoattractant protein-1 (MCP-1) in an early stage of DN [20, 21]. This evidence concerns the gene CCL2 and liver dysplastic nodule.