In another study using the iminosugar N-(5-adamantinane-1′-yl-methoxy)pentyl-1-deoxynoijirimycin(AMP-DNM), an inhibitor of UGCG also did not raise ceramide levels in liver and maintained the plasma level of ceramide to basal level in diet-induced hyperlipidemia in apoE−/− mice [14]. This evidence concerns the gene UGCG and hyperlipidemia.