However, the multivariate analysis indicated that lymph node metastasis (HR 2.185; 95% CI 1.276 to 3.740; P = 0.004), male sex (HR 1.782; 95% CI 1.061 to 2.993; P = 0.029), and MTA3 expression (HR 0.442; 95% CI 0.275 to 0.708; P = 0.001) were independent prognostic factors (Table 3). The gene discussed is MTA3; the disease is metastatic malignant neoplasm in the lymph nodes.