TRPV1 is expressed not only in neurons but also in mast cells [64], [65], but further more studies needed to identify the cell origin.Evidence shows that TRPA1 channels identified in non-neuron cells including lymphocytes [66], and genetic deletion of TRPA1 drastically attenuates inflammation and hyper-reactivity in a mouse model of asthma [67]. The gene discussed is TRPV1; the disease is asthma.