HMOX1 and disease arising from reactivation of latent virus: Further analysis revealed that HO-1 was the most powerful parameter for discriminating pulmonary from EPTB although with a reduced accuracy compared to that seen in the discrimination of active from latent infection (Figure 2D; PPV: 79.3%, 95% CI: 68.6–87.1%; NPV: 36.4%, 95% CI: 22.4–52.2%).