On the other hand, we could not observe the significant increase of NCoR and NCoR phosphorylation in LNCaP-derivative C4-2B cells when compare to both DU145 and PC-3 cells, suggesting that NCoR phosphorylation by CK2 may be directly relevant to malignancy of prostate cancer cells rather that hormone independency. Here, NCOR1 is linked to Familial prostate cancer.