In both healthy and T2DM subject populations, the prodrug, remogliflozin etabonate was extensively converted to its active entity, remogliflozin, and to an active metabolite, GSK279782, which is as potent as remogliflozin in inhibiting SGLT-2 in vitro [23]. The gene discussed is SLC5A2; the disease is type 2 diabetes mellitus.