In T2DM subjects, the median baseline adjusted AUC(0–4) for plasma GLP-1 following an OGTT was 6.36 pM*h (range, 0 to 16.6) for placebo, -8.85 pM*h (range, -46.7 to 33.4) for remogliflozin etabonate 50 mg, and -1.95 pM*h (range, -11.6 to 7.0) for remogliflozin etabonate 500 mg. The gene discussed is GCG; the disease is type 2 diabetes mellitus.