Given that over 50% of BM in HER2-positive and TNBC occur in the first year after diagnosis of metastatic BC in this study which is compatible with previous reports (Heitz et al. 2009), it might be reasonable to confine candidates to screen asymptomatic BM to HER2-positive and TNBC population, for more risky period after initial diagnosis of metastatic disease, and screening should be considered incorporated with systemic disease control. The gene discussed is ERBB2; the disease is metastatic neoplasm.