MMP2 and esophageal squamous cell carcinoma: To further explore whether SLP-2 overexpression increasing ESCC cell invasive ability was due to the induction of MMPs, we used RT-PCR analysis revealed that the knockdown of SLP-2 in both KYSE510 and EC9706 cells drastically repressed MMP-2 expression at both mRNA level and protein level (P<0.05, Fig. 2Ca,b, 2Da,b).