Knock-down of ALK by siRNA [8], [11], or ALK inhibition by small molecules PF-2341066/Crizotinib [10] and TAE684 [9] leads to suppressed cell growth, with decreased proliferation and increased apoptosis in neuroblastoma cells harboring mutated or amplified ALK. Together, these studies in neuroblastomas suggest that in a normal cellular context, appropriate ALK expression and activity levels need to be maintained for cell proliferation and survival. Here, ALK is linked to neuroblastoma.