CCL21 and breast carcinoma: Analysis of HS578T-Hyg cells showed a marked inhibitory effect of U73122 on the cells migratory activity, which was similar to U73122 plus CCL21 treated cells (U73122: 38±7%; p<0.001; U73122 + CCL21: 29±8%; p<0.001; Figure 5A) indicating that the matrix induced migration of HS578T-Hyg breast cancer cells depends on PLC-β/γ signaling.