In a similar vein, c-Fos staining shows an initial reduction in cortical activity post-TBI [51] These “global” depth-dependent suppressive effects are consistent with the strain (stress) wave known to propagate through the skull and underlying brain tissue on head impact [17], [30]–[34].It has been reported that by 3 days after brain injury, evoked potentials from somatosensory cortex have significantly longer latencies and reduced field potential slopes [52], which is in line with decreased metabolic activation that occurs as early as 4 hours and up to 24 hours after injury [53]. This evidence concerns the gene FOS and brain injury.