Therefore, various therapeutic applications to enhance tumor immunity have been attempted, including anti-TGFβ antibodies, anti-CCR4 antibodies, anti-CTLA4 or Programmed Death-1 (PD-1) inhibitory molecules, TLR7 or Bacillus Calmette-Guerin (BCG) boosting therapy, and IL-2 or IFNγ treatment. Here, TGFB1 is linked to neoplasm.