Heavy drinkers (≥24 g/day) without metabolic syndrome had a high risk of elevated liver enzyme levels (OR: AST: 3.73 [2.54–5.47], ALT: 1.61 [1.00–2.60], GGT: 7.81 [6.07–10.06]), as did moderate drinkers (<24 g/day) without metabolic syndrome (OR: GGT: 2.61[2.06–3.32]), demonstrating the independent risk conferred by alcohol consumption. This evidence concerns the gene GPT and metabolic syndrome.