HCRT and Alzheimer disease: While to date no data on MCH levels in AD exist, literature concerning HCRT-1 is heterogenous: whereas immunoreactive neurons in postmortem hypothalami and ventricular cerebrospinal fluid (CSF)-HCRT-1 levels in AD patients were found to be reduced [25], lumbar CSF levels in vivo were unaltered [26], [27], [28].