In addition, we demonstrate that two SOX2-associated proteins, MSI2 and Ubiquitin Specific Peptidase 9x (USP9X), which have been recently implicated in the growth of other cancers [16]–[21], are required to support the growth and survival of DAOY cells and two GB tumor cell lines, U87 and U118. The gene discussed is MSI2; the disease is cancer.