Two examples of BCL-2 misregulation are the occurrence of the BCL-2 gene as part of the t(14;18) translocation found in a number of non-Hodgkin B-cell lymphomas [23] and the increased expression of BCL-2 in different cancers, in which elevated levels correlate with chemoresistance [24]. The gene discussed is BCL2; the disease is B-cell non-Hodgkin lymphoma.