Of note, BCL-XL can be transcriptionally regulated by the NF-κB, JAK/STAT, AP-1, and Ets transcription factors [45], [46], MCL-1 is a transcriptional target of STAT3 and both are often up-regulated in aggressive lymphomas [47]–[51], and BCL-2 is routinely associated with the ABC DLBCL subtype and increased NF-κB activity, and has been shown to be a transcriptional target of STAT3 [47], [52]–[55]. This evidence concerns the gene STAT3 and lymphoma.