Additionally, in NZB/W F1 mice, a mouse strain that develops an autoimmune condition accepted as a murine model of Systemic Lupus Erythematosus [41] and that has a large B-1 cell population in the peritoneal cavity [7], spontaneous production of IgG anti-DNA antibodies by splenic B cells was enhanced by IL-6 [42]. The gene discussed is IL6; the disease is systemic lupus erythematosus.