Using a transgenic zebra fish, Liu et al. [64] (2011) demonstrated that R-roscovitine, a CKD2/cyclin E inhibitor, was able to suppress ACTH expression, promotes corticotroph tumor cell senescence and cell cycle exit by up-regulating p27, p21 and p57, and downregulating cyclin E expression. The gene discussed is POMC; the disease is neoplasm.