In addition, carcinoma prostate cells treated with lycopene (2.5–10 μM) reduced intracellular total cholesterol by decreasing enzymes related to cholesterol biosynthesis and by inactivating Ras also accompanied by an decrease in cyclin D1, phospho-Akt levels and by a increase in p21, p27 and p53 levels, and the Bax/Bcl-2 ratio [40]. This evidence concerns the gene CDKN1B and carcinoma.