TNFSF12 and autoimmune disease: Imbalance in the regulation of TWEAK in the process of inflammation and immune modulation leads to the development of chronic inflammation and autoimmune diseases like rheumatoid arthritis [20], [42], systemic lupus erythematosus [43], [44], neuroinflammation [16], [45], multiple sclerosis [46], [47] and ischaemic stroke [48]–[51].