It is likely that aberrant methylation decreases the expression of multiple tumor-suppressive miRNAs, such as miR-224, -452, -340 and -181c, which then induce over-expression of multiple oncogenic genes, like KRAS, DPYSL2, and MECP2. These abnormal multiple-to-multiple relationships between miRNAs and targets would be one of the important mechanisms underlying gastric carcinogenesis. This evidence concerns the gene DPYSL2 and neoplasm.