While the absolute numbers of FoxP3+ cells associated with SCC were similar to TSCC, the proportion of FoxP3+cells r to cytotoxic (CD8+) T cells was significantly increased (∼2 fold) in TSCC (TSCC 0.97±0.22 vs. SCC 0.45±0.05, p<0.05; Figure 2d), indicating a tumor permissive environment in TSCC. This evidence concerns the gene FOXP3 and neoplasm.