Many aspects of VEGF and semaphorin signaling depend on other cells in the tumor microenvironment, in particular endothelial cells and tumor stromal cells, and an analysis of cell lines could aid in determining which differentially expressed ligands in the present study arise due to tumor cells and which are due to stromal cells; as well as insight into whether observed receptor expression variation is due to tumor cells or tumor-associated endothelial cells. Here, VEGFA is linked to neoplasm.