Conversely, the direct overexpression of mir-7 together with Dl (hereafter, ey>Dl>mir-7), using a mir-7 transgene that does not contain any bl sequences (UAS-mir-7), provoked overgrown larval eye discs ey>Dl>mir-7 (Figure 1H; compare with sibling wild type eye discs, Figure 1I) associated with significant increased cell proliferation (Figure 1J and Figure S4C–D,H), resulting in adult overgrown and folded eyes similar to that in the GS(2)518ND2 flies (70% of adult ey>Dl>mir-7 animals displayed eye benign tumour-like growth, n = 200; Figure 1K and Figure S2A–C). The gene discussed is EDAR; the disease is neoplasm.