NLRP3 and gout: Additionally, endogenous DAMPs such as extracellular ATP, gout associated uric acid crystals (Martinon et al, 2006), fibrillar amyloid beta (Halle et al, 2008) or cholesterol crystals (Duewell et al, 2010), and also environmental products like silica crystals (Hornung et al, 2008), asbestos fibers (Dostert et al, 2008) and nanomaterials (Yazdi et al, 2010) have been shown to give rise to NLRP3 inflammasome activation.