PSEN1 and synucleinopathy: Immunohistochemistry to visualize pTDP-43 (S409/410) was performed on mouse models of Aβ amyloidosis (TgCRND8, Tg2576, and Tg2576/P264L PS1), tauopathy (rTg4510 and JNPL3), α-synucleinopathy (Lines M47 and M83), HD (HD586-82Q), and non-transgenic (NT) controls at time points when each model has robust aggregates of their primary pathologic protein (e.g., tau in rTg4510 and α-synuclein in M83 mice).