GRN and amyotrophic lateral sclerosis: Familial forms of FTLD-tau are associated with mutations in the MAPT gene that encodes the tau protein, whilst mutations in Granulin (GRN), Valosin Containing Protein (VCP), or C9ORF72 genes can cause FTLD-TDP or amyotrophic lateral sclerosis [3, 10, 22, 54].