Consistent with the established relationship between inflammation and the progression of atherosclerosis,27–28 we observed that recombinant angptl2 upregulated the inflammatory cytokines TNF‐α and IL‐6 in ECs freshly isolated from the aortas of WT and ATX mice and within 10 minutes in cultured human ECs (Figure S2). This evidence concerns the gene TNF and atherosclerosis.