Interestingly, angptl2 expression is higher in hIMAECs than in HUVECs (Figure 7), likely because of the elevated level of oxidative damage sustained in vivo.23,39 The elevation in circulating angptl2 associated with the progression of atherosclerosis in ATX mice (Figure 5A) and its accumulation in plaque (Figures 5B and 5C and 6A and 6B) strongly suggest that angptl2 contributes to the pathology. The gene discussed is ANGPTL2; the disease is atherosclerosis.