SLC34A2 and chronic kidney disease: Another interesting observation in adenine-treated NaPi-IIb+/− mice was a decrease in serum creatinine levels, suggesting that reduced NaPi-IIb activity might also limit CKD progression; however, this apparent renoprotection was not seen in the NaPi-IIb−/− mouse with adenine-induced or surgically induced renal failure, even when serum phosphate levels were normalized with binders [34▪▪].