LRRK2 and Parkinson disease: Here, we report a patient with a clinical diagnosis of Parkinson's disease, who in post-mortem was found to have nigral degeneration without Lewy body pathology, and was also shown to carry the LRRK2 G2019S mutation and a novel heterozygous variant c.370C>G, p.Q124E in exon 4 of the microtubule-associated protein tau (MAPT).