TARDBP and Alzheimer disease: In addition to FTLD-TDP and ALS, TDP-43 inclusions can sometimes be detected in other neurodegenerative diseases including AD, Lewy body disorders, and primary tauopathies including corticobasal degeneration, PSP, parkinsonism-dementia complex of Guam, and dementia pugilistica (Arai et al., 2009; Hasegawa et al., 2007; King et al., 2010; Mackenzie et al., 2010; McKee et al., 2013; Uryu et al., 2008; Yokota et al., 2010).