TARDBP and amyotrophic lateral sclerosis: Ubiquitinated TAR DNA-binding protein–43 (TDP-43) is a major disease protein in FTLD and amyotrophic lateral sclerosis (ALS) and can occasionally be observed in Lewy body disorders and tauopathies (Mackenzie et al., 2010; Neumann et al., 2006; Sreedharan et al., 2008).