MICE and leukemia: In the mice models, the expression of the NRASD12 was induced in the adult bone marrow cells, the adult hematopoietic organs, and caused dysplastic myelopoiesis/leukemias with long latencies (> 4 weeks), which highlight the possible requirement of a definitive hematopoietic environment and the length of time to accumulate cooperative genetic mutations for the development of NRASD12-associated leukemia [36].