Disseminated fungal sepsis frequently occurs as a secondary hospital acquired infection in ICU patients with impaired immunity [9,10].In order to mimic the state of impaired immunity that exists in ICU patients, sub-lethal CLP was performed prior to Candida infection as described previously [13,27].Mice underwent CLP followed three days later by Candida challenge.Mice were treated by i.p. injection with either anti-PD-1 or anti-PD-L1 antibody or saline diluent (control) starting 48 h after Candida infection. This evidence concerns the gene CD274 and candidiasis.