We have determined that differential expression and localization of CARM1 is associated with two molecular subtypes of breast cancer (HER2+ and basal-like) but could not identify an association with the histological subtypes or pathological progression of tumors from DCIS to metastasis. We conclude that the sub-cellular localization of CARM1 is somehow related to the specific differentiation of molecular tumor subtypes. Here, CARM1 is linked to ductal breast carcinoma in situ.