The levels of these IgE-abs in sera of severe AD patients were significantly higher (pre-school age children: keratin – 2.16 (5.58) ME/ml and to elastin – 1.81 (0.49) ME/ml; school age children: keratin – 2.71 (12.29) ME/ml), elastin – 2.69 (1.38) ME/ml) in comparison with both mild AD patients (pre-school age: keratin – 1.4 (5.6) ME/ml, elastin – 1.4 (1.0) ME/ml; school age: keratin – 1.7 (4.68) ME/ml), elastin – 1.4 (1.07) ME/ml) and healthy children group (p < 0.05). The gene discussed is IGHE; the disease is Alzheimer disease.