This IHC signature "HER2(3+) OR GCDFP15(+)" had a sensitivity and a specificity for apocrine tumors of 94% and 100%, respectively (Table 4) and is also shown in a tree diagram displaying the best possible marker combination to discriminate MA and BL tumors in the ER negative context (Figure 4). This evidence concerns the gene ESR1 and Burkitt lymphoma.