We analyzed whether cytokine genes have different effect on GBM in gender specific population, and found that the allele “G” of rs2243248 in the IL-4 gene showed a decrease risk of GBM in female (OR = 0.35, 95% CI, 0.13 – 0.94, p = 0.0032), but the allele “T” showed a decrease risk in male (OR = 0.30, 95% CI, 0.17 – 0.53, p = 0.0032). Here, IL4 is linked to glioblastoma.