In the multivariate logistic regression models (Table 3), each of the variant genotypes of LIG4 rs1805388 was associated with a significantly increased risk of gliomas compared to the wild-type CC genotype (adjusted OR, 1.62; 95% CI, 1.20-2.18 for CT and adjusted OR, 3.27; 95% CI, 1.87-5.71 for TT, respectively). This evidence concerns the gene LIG4 and central nervous system cancer.