TRPC6 and nephrotic syndrome: The reported mutation is novel, as it has not been seen in over 90 patients with nephrotic syndrome sequenced in our laboratory, is not reported in any dbSNP or exome sequencing databases of normal controls, and has not been previously reported in TRPC6. The resultant frameshift leads to a premature stop codon, and is predicted to result in a truncated TRPC6 protein lacking the C-terminal coiled coil domain.