In 17-month-old BRI2-Aβ1-42 mice, amyloid plaque pathology as well as RIPA soluble and insoluble Aβ levels were comparable to levels found in APP CRND8 mice at the age of 4 months (Figure 1E-F, and H), when CRND8 mice showed reliable cognitive impairment in our previous studies [9,13]. The gene discussed is APP; the disease is Cognitive impairment.