Rarely TTF-1 has been found to be expressed in some ovarian tumors but in a recent study, TTF-1 expression significantly improved progression-free (p=0.017) and overall survival (p=0.017), and was identified to be an independent prognostic factor for ovarian cancer in multivariate analysis (p=0.047)[19]. The gene discussed is TTF1; the disease is ovarian neoplasm.