ZC3H12A and stroke disorder: Considering the other experimental results in this study, including that MCPIP1 can be significantly induced by EA treatment in the brain, and that MCPIP1 has been identified as an important inducible anti-inflammatory regulator in stroke pathophysiology [28], it would appear more likely to that MCPIP1 actually participates in the EA pretreatment-induced ischemic tolerance.