CDC6 and human African trypanosomiasis: Since T. cruzi and T. brucei use archaeal-like Orc1/Cdc6 as the initiation factor, screening of specific inhibitors that only target TcOrc1/Cdc6 and TbOrc1/Cdc6 ATPase activities but not that of human pre-RC would greatly benefit the treatment of American and African trypanosomiasis (Figure 2).